The grip on the Witness is one of the things that sold me on it, I also have small hands (size 7 glove) but the Witness just snugs down and purrs like a kitten. One of my basic rules about handguns is that if your hand doesn't like it, you will NOT shoot it well. I have looked at the Witness Compact lately, it has some appeal, but I really like my full-size Witness, with a steel frame. It balances well, doesn't kick much (to me, anyway), and speaks with authority. With pre-ban mags it holds 13 rounds of 40SW, and that beats seven rounds of 45, in my book. Better to have and not need, than need and not have, as they say.
Reliability is still the biggest factor in picking my Ohcrap Gun, and this one is. It handles bullet weights from 135 to 200 grains, and that covers velocities from 1300 down to about 850 fps, the latter of which pretty much duplicates 45ACP ballistics. Hope this helps.
PJ