"Can't" is a very strong word, but I think it would be pretty difficult. Moon clips are made to shoot .45 ACP in .45 Auto Rimmed chambers, not .45 Colt. Headspace would be all wrong and I don't think the extractor would work. It might be possible to install a .45 ACP extractor and let the round headspace on that, but the bullet would have an awfully long jump the the rifling. It's already extra long due to the .410 part of the chambering. I don't think accuracy would be very good. If you want an ACP barrel, you'd be better off buying one, in my opinion.
RonF