I would probably choose between the 445 supermag and the DW460. The first because it is as close to a 454 as DW makes, and the latter because it is just kind of unique, and I will be loading 45WM anyhow.
This is just pie-in-the-sky thinking about a new pistol, but we know where these things end up
They list it under their "Large Frame Revolvers". How strong are these? And have they improved the cylinder latch from years ago?