I can't tell if you are talking 44 special or 45 colt. The SAA clones in 45 will handle loads up to something around 12,000 psi, maybe a little more. That is pretty much a regular cartridge from any of the manufacturers. They just won't handle the +P loads. For really heavy loads you will need a Blackhawk.
Update: Here is a quote from Chuck Hawks from his article on high pressure 45 colt loads. "For the purposes of this article, by "high pressure" I mean pressures above the industry accepted SAAMI maximum pressure limit. For the .45 Colt cartridge that is 14,000 psi as measured by the relatively new piezo-electric transducer method, or 15,900 cup as measured by the older copper crusher method."
I said around 12,000 psi and he says the industry standard is 14,000 psi. If you are in the neighborhood with your reloads, go closer to 12,000 than 14,000. You won't know the difference and your gun will last longer.