Comments have come from Ruger through various channels before that after tests the thinned frames (to get in the oversized cylinder) do not hold up well enough to suit their liability lawyers (Ruger is too big of a target under the "deep pockets theory"), so until there is enough demand to create an even larger framed single action (keep thinking Super Redhawk, not Redhawk) the answer to the question is no. That's why we are left to BFR, FA and handmades.