The 25-06 has more ammo selections than the 7-08. The 25-06 normally has a 24" barrel or longer and the 7600 only has a 22" barrel so there will be a bit more noise. The 7-08 would have more capability on larger game with the heavier bullets available. They probably kick about the same in a 7600. The 25-06 is king of the dual purpose cartridges (.243,6mm Rem,257 Rob). The 7-08 seems to slowly gain in popularity.