I don't know about everybody else, but I shoot my BRNO 22 way better than anything else- mainly because I know it isn't going to kick- and therefore I don't flinch.On that basis, I think you're better off using a lighter calibre if you can shoot it more acurately.I rememer tellung my gunsmith I was looking for a 338 to go moose hunting, and he asked me what was wrong with my 6.5x55 swede?He pointed out that I was used to the 6.5, and that I would likely be better of shooting a lighter calibre gun ifI could shoot it accurately than a new heavy calibre gun I wasn't used to- and would possably flinch.His concept was , sitdown, or use a rest, shootingsticks, whatever, take one careful shot behind the shoulder and wait 20 minutes before following up.