R C
Years ago when I only had a couple of rifles, I was going elk hunting in Northern Colorado (not far from where I lived). I was practicing with my main elk rifle when the crosshair (a Redfield Scope) broke.... Couldn't get it fixed in time for the season, so I took my second rifle, a Ruger #1 H in .375 H.H.... "A real pig to carry!"
I used Hornady (still do) 'interlocks', 270 gr. bullet, don't remember the powder charge, but it would of been close to max.
I didn't get an elk that year, but did take a mule deer with that gun and cartridge. The deer was on full alert when I hit it with the .375. High heart/lung shot, broadside. The bullet passed through (no duh), the deer flopped over on its side, legs kicked, once. It was dead. The heart was 'exploded', looked like the liver.
And as Elmer Keith always said, "you could eat right up to the hole!"
It made me a believer of the .375 that day, I currently own and use 3 different, encluding that Ruger #1