I don`t load much .45 Colt ammo, But I do load alot of .357, both mag. and max., .44 mag. and .454. My favorit powder is Win. 296, which is about a twin for H-110 so is you have it use it. I also like the WLP so you`ve got that covered. Load at or near max. with a good jucketed bullet, I find that I usually get my best mix of accuracy and terminal preformance with Serria bullets. If you chose cast bullets for hunting get a good Keith style bullet that is hard cast and gas checked. As for a jacketed bullet I would recomand you try the Serria 240 grn.JHC bullet. You should be able to push it to 1,250 fps. in your Ruger. For practice ammo get some good hard cast bullets240 to 250 grn. range and push them with 5 to 5.5 grns. of Bulleyes powder and use the same WLP primers.