If you have set of Lee dies, make ABSOLUTELY certain that they say carbide, and that you're not assuming that all dies are carbide dies. Many pistol dies are carbide dies, many bottleneck rifle cartridge dies are not carbide dies. The difference between the two lies in the molecular structure, which I will not get into, but KNOW THIS. If your dies DO NOT say carbide for your bottle-necked cartridges, you need to lube them with a good case lube. Lyman, Lee, RCBS, etc. all make lube kits. If you try to run the cartridge up the dies without the lube you'll get it in, but you won't get it out, it will get stuck, trust me, I've been there. Now the Lee dies come in a set of 4 that you have apparently purchased, one should say FULL LENGTH RESIZING DIE (then it should name the caliber, say, .308 Winchester). Put this die in, run the ram of your press to the top, screw the die in until it contacts the ram, then back off a half-turn, should be able to fit a nickel in the gap between the ram at it's highest point and the bottom of the die. Set your locking ring there, you've now adjusted the die to resize the brass to chamber in 95% of .308's made. Lube up your cases and resize them. This die will resize the body of the case, the neck, and punch out your primer. From there, if you've loaded a pistol, you know what to do, except you don't need to expand/bell the case mouths to seat your bullets. There are other ways of setting up your resizing dies that involve a little work and some fired brass from YOUR gun, but you wanted general information and I gave it to you, this is also how you should set up your dies if you intend to hunt with your rifle, they'll chamber easier and the accuracy difference is measure in tenths and hunredths of an inch, not in minute-of-a-deer. I hope this helps, if you have any other questions, just ask away, we're here all day!
Selmer