I have fooled around with reduced loads quite a bit. Accurate powder has reduced loads for almost every cartridge in thier book ...usually using XMP 5744. I have used it a lot...even for my Ultra-Mag. 168 gr Hard-cast, less than 1600 fps, and no signs of excess pressure or problems. The Speer manual also lists reduced loads with 5744, IMR 4198, and mostly SR 4759 powders. I would follow a precise recipe for starters...there are a lot of published loads in the books and these are tested and considered to be safe.