Elwood and TC_Addict: Tubbythetuba and Redhawk have provided some excellent information.
In truth, there is very little difference between the 45 auto and the 45 Colt, in terms of their velocities and overall performance. I'm not talking about the 45 Colt loads from the higher pressure revolvers, I'm simply referencing the older, more original 45 Colt loads.
The 45 acp can be loaded to the 45 Colt level of performance, which is basically dependent upon the bullet design. I have always been an advocate of a cast, flat nosed bullet at fairly modest velocities (850-900) for personal defense, in the 45 calibers. It just seems to work.
Since we are talking about hunting and not personal defense, then we have to recognize that there is very little difference, if any practical difference at all between a 225 gn flatnose bullet at 875'/sec from the acp and a 255 gn swc at 850 from the Colt. However, neither is a preferred hunting round and the concern is whether either would give adequate penetration at better than 50 yds.
If it is in a survival situation and the acp with an adequate bullet is all you have then you simply must do with whatcha got - but again, it is not a preferred choice. Yes, it is a big fat slug moving at modest velocities and will penetrate through and through out to a certain distance but beyond that it loses steam and capability fairly rapidly.
Somewhere I saw an add for a 230 gn flat nose bullet someone was casting for the 45 Schofield but I simply have not been able to locate that add since first seeing it. I could easily be convinced this might be the best all-around bullet for the 45 acp for defense and this would certainly do for hunting in a survival situation if the 45 acp was all you had. Keep in mind though that the bullet would be loaded to probably no more than 900'/sec and even if you could squeeze another 50'/sec from the load it would still limit you to a 50 yd maximum distance.
I have seen 45 target shooters plunk 230 gn ball into a 2" group at 50 yds. If you could place your shot right it would bring down a deer sized critter but again, there are better choices.
Now, if I could only find that add again I think I would be happier. HTH and this is just my own 2 cents worth here. Mikey.