The Casull 454 will only handle a .4 nose length, and for it the WFN will give maximum powder room, which is only needed if you want screaming speeds, of 1700 fps+ with a 340 gr. A 325 gr will work fine for anything you mentioned when started at speeds down to 1200 fps, so powder room isn't a factor in getting very good working loads.
The WLN has the same meplat as the WFN but allows a longer nose length for guns with cylinders which permit noses of .450 (Ruger Blackhawks and S&W's) or .500 nose for Redhawks Anacondas,etc.
The LFN is suited to any nose length from 400 to well over .500, and punches a somewhat smaller wound than with WLN or WFN, assuming similar impact speeds and caliber.
You will not have penetration problems with any of them on game up to moose and large bears.