Be aware that the chart offered by Precision Bullet is designed for saboted rounds and bullet diameter only.
Your .54 will not shoot .54 cal bullets using a sabot. Precision Bullet will offer for your .54 a series of sabot style bullets in .44,.45 and 50 for your .54.
Now, depending on your guide and circumstance for Caribu,distance and accuracy, not knock down power is best, Caribo are wimpy, they ain't moose or bear, they have a light frame over the vitals and tend too bleed out quickly with proper placement.
When hunting different big game, one should study "end ballistics" of different projectiles,,,,,,,,,,,,big, long, is not always good.
If you want 2" 100yrd accuracy from a .54, something in the range of 300 to 380 is proven to be best. The object is to deliver and expend the energy of the projectile on contact with the target/game.
A 430grn bullet flying sideways and begining to tumble at 100yrds,cain't do as much too game as a prb that will "thunk" push and tear the "boiler room".