Hi Billy,
I cant' add much, to what already been said. I just wanted to say, I've been hunting with singleshots for over 30 years. And never really felt a logical need for anything else. Granted, when I was younger I had a SS .22, and my buddies were using repeaters, I felt somewhat lacking. But I killed as much game as they did, with a whole lot less ammo!!
Patience, is the key. As with any firearm, wait for the "ethical" opprituninity, and make a accurate, clean shot. A follow-up, shouldn't be needed. Only when hunting "dangerous game", would I think twice, about not using a singleshot. And even then, because I don't feel handicapped and, that I'm more comfortable and familiar with a SS, that's what I would prefer too use.
Dave