As a Southern Michigan resident who hunts with a 300 yard muzzleloader, I see a huge difference between my gun and a .30-06! Do a little research into the ballistic comparison. For the .30-06, a 300-yard shot is easy...sight in 3 inches high at 100 yards and you'll hit the vitals at 300. With my ML, I am 4.5" high at 100 to get a 200 yard zero, and about 18-19" low at 300 yards. If you carry those trajectories out past 400-500 yards, the differences will become HUGE due to the projectile BC differences.
While we might be stretching ML technology to get 300 yards, this is really like shooting a .30-06 at 700-800 yards, minus the aiming difficulty of the long distance. You can easily loft a .30-06 bullet into your neighbor's vicinity, but the ML bullet won't make in more than a couple hundred yards further than the shotgun slug would have.
Plus, a ML is still one shot. With a rifle Joe Schmoe Yahoo can loft 4-5 bullets at long range at a fleeing deer once he misses the first aimed one instead of having to stop and reload. HUGE gain in safety just from that fact. It's nice to think that all hunters are moral and responsible, but we must admit it just aint' so!