I'm not sure of the terrain your hunting, but i'll say that the 25-06 is a seemingly under rated cartridge for deer sized animals. Makes a great beanfield round, but under normal hunting conditions, with a max of 300 yard shot, both should perform to your likings. The 25-06 will shoot a little flatter though, with a more recoil. It might just come down to, do you want a short or long action. And I prefer short actions for deer. Not to mention, the .260 is kinda cool. :wink: