Huntsman,
I'm not throwing stones, but the paragraph that I quoted sounded very generalized and this question can't be answered with a general answer.
A hit in the forward spine or brain area with enough bullet and velocity will certainly take an animal down on the spot. Knockdown? I don't think so! Bob Hagel has written about a mule deer that he took and during the cleaning he found a bullet lodged against one of the neck vertabrae. Not his bullet, but the bullet of another hunter of days past. Not enough bullet or velocity. Why he recommends against head and neck shots.
It is the bullet strikes in the heart-lung area that we have come to think of as creating "knockdown power".
I have taken whitetails with a number of cartridges over the span of about 30 years. I always go for the heart-lung area. The 30-30 didn't "knockem down". The .35 Remington didn't either. The 6.5x55 didn't, nor did the .270 Win. Neither the 7mm Rem Mag nor the 7mm-08 Rem did the deed. In each case the bullets from the above cartridges penetrated completely.
Only two cartridges have accomplished this feat for me. The .45-70 and the .243 Win. The .50 cal. muzzleloader has also done this. The bullets from the .45-70 and the .243 penetrated completely. Some of the .50 cal. bullets didn't.
Certainly, the .270 Win and the 7mm Rem Mag create more energy than the .243 Win., but they didn't "knockem down". So, it can't be an "energy thing" alone. After all, FMJ bullets can carry the same energy down range as their soft-nosed counterparts. A shot in the heart-lung area with a FMJ won't "knockem down", either. Other folks have also experienced the same performance from the .243 Win. But, there is nothing magical about "knockdown power"
In P.O. Ackley's books it is referred to as the result of "hydraulic shock". If a bullet of a certain construction creates enough "hydraulic shock" when it enters the heart-lung area, it literally shuts down all motor functions. Laboratories sometimes use "ultra-sounds" to mix or break down a product. These ultra-sounds send sonic waves through water and the product. Similar to the "hydraulic shock" created by some high speed bullets.
Obviously, it is velocity coupled with the right kind of bullet construction that produces most of the instantaneous kills that are referred to as "knockdown".
Mr. Ackley created a little hummer called the .17 Ackley Bee. It fired 20g and 25g bullets into the 4,000-3,800 fps. range. It was reported as instant death on mule deer, sheep, coyotes and smaller critters. Under 200 yds. the little bullets exploded inside the vital areas, producing quick kills. This has also been seen by folks usng high speed .224's.
I have found that "knockdown power" can be produced by bullets that penetrate completely, penetrate-but stay inside and by bullets that explode within the carcass!
And clodbuster, I agree. I would much rather have a good blood trail!
Just rambling,
Buffalogun