cotton can form into balls that wont keep the powder against the primer.It wont compress as much as poly,and MIGHT become a secondary projectile. This could result in a "ringed" chamber. When kapok was all the rage, some guys did not add enough to give a slight compression of the filler. Many guns were damaged by this mistake. Cereal fillers also need some compression to keep them between the powder and bullet. One half grain of poly wadding will keep almost any charge against the primer and usually burns away before exiting the muzzle. It leaves practically no residue,improves internal ballistics and accuracy. I found poly to be the best filler in 45-70 ,30-06 and other large cases when loading lite plinking loads.You may try fooling around with other fillers( I DID) before you come back to poly. That's what makes reloading so much fun!