Regarding reduced loads, I have a Model 70 Winchester in .416 Remington Magnum. One load that I have used quite a bit features Remingon brass, Federal 215 magnum primers, 72.5 grains of IMR 4895, and the 350 grain Speer Mag Tip. This is a good load to use for practice and it is still fast enough for hunting. I've chronographed it at 2,450 fps which means it would have about 4,600 foot pounds of muzzle energy. Out to 200 yards or so that ought to make a good elk, moose, and bear load without beating your shoulder to death.