I have both Kirst and R&D cylinders in Remingtons, and in that revolver, prefer the R&D, as the Kirst seems to be harder on the softer Italian mating parts like the nose of the hand, and I see no advantage to a ported Remington, as you can change out the whole cylinder faster than you can reload through the port. That said, I prefer the ported Kirst on the Colt 51/61 Navies, as removing the barrel to reload an R&D is not practical, or good for the wedge and slot.
I recently opened the rim recess in my 45 cal R&D cylinders with a 17/32 end mill to accept the 45 Schoffield round, and that is a better cartridge for lighter loads, (smokeless or black) being shorter. While at it, in the mill, you can cut a window to see the brass rim, which is easier to check than the color coded firing pin.