Geez, that's kinda leaving the door open, but in reality, shot placement is more important than the caliber, for the most part. That said, the .45-70 is a real favorite here as well as the .270, .280, 7mm-08, .30-30, .308 and .30-06. All are fine calibers and when used within their respective effective ranges, will kill deer very well and quickly. The .45-70 is the most fun to shoot, too! :wink: