While I agree with GB on this issue, not all experts do. Lee Jurras made a pretty good living loading 180-grain .44 Mag ammo (among a lot of other SuperVel stuff) , and he shot a LOT of game with that load. His secret was to use a non-expanding jacketed bullet to gain penetration. Again, not my cup of tea, but another valid viewpoint. Late 19th century hunters gravitated to Express cartridges using much lighter than normal bullets to gain velocity and killingpower, this in calibers up to .450" and more.