I use 100gr of 777 3F in my .50 GPH flintlock behind any of the powerbelts. My gun seems to prefer either the 295 or 348, 245s are OK but I get slightly better accuracy with the heavier bullets. My twist is 1:32 so this makes sense.
I don't use the blackpowder primer, just blackpowder in the pan. I get reliable ignition but I think slightly more delay than 100% blackpowder.
Approximate ballistics with this setup are just a tad under 1700fps, 3 high@50, 3 high@100, zero @150. Accuracy is very good out to 150.
About every 3-5 shots I clean the BP gunk out of the pan, about every 10 shots I run 1 or 2 damp patches to clear out the ring that may build at the bottom of the barrel. I've gone 20 shots without any barrel cleaning and things were still smooth except I could feel the ring at the bottom, but it never seemed to create a problem.