Will and Filmokentucky basically said it. The typical cartridge bullet is up to twice as heavy as a round ball, also usually harder lead. The cartridge is much more efficient than loose powder and ball, and generates more pressure. The bullet slamming into the forcing cone is trying to pull the cylinder pin out of the gun, and eventually will. A brass frame just amplifies all the weaknesses of the open top design, and even in the Remington design will stretch a brass frame. The brass or bronze frame was a wartime emergency solution for the Confederacy's arms shortage. Bronze gunmetal was only used otherwise in very small low powered pocket pistols.
When Winchester chambered the 44-40 WCF cartridge, they went back to iron for the frame in the 1873 model. The newly made repro Henrys and 66s are made of a much stronger bronze than was available a century ago, and can stand the "Cowboy" loads we use in CAS.
One thing I noticed was how poorly Pyrodex works in a muzzle loader compared to real black powder (The pellets work better), but it seems to work very well in cartridges. Black powder also seems to shoot cleaner and better in a cartridge. I believe it is the better compression and hard crimp on a heavier bullet in the cartridge, also lacking is the gas leak through the nipple.