I don't concider a 22LR or a 22mag the best round for coyotes, but in some areas, thats all you can use,rimfire only, be sure to take a head shot or heart/lungs or like Graybeard said they will be in the next state before he dies, if he does. I have used even a 22lr using the new CCI Raptors GDHP bullet, they state 33% more energy, I use a bait sight, get them in close and head shot them. I prefer a scoped 243win using 100gr hornady interlocks FB/BT...terns them inside out, not good if you want to save the pelts;) Aim small hit small. RAMbo.