I didn't know the .500 used gain twist. I had read the .460 was - starts at 1:100 and ends up around 1:14. Sounds like it would be awful with cast bullets, since the shape of the rifling imprint on the bullet would change and cause gas to leak past.
As for the .243's twist, it takes 1:8 to stabilize 107 VLD bullets, but normal 100gr. hunting type bullets are fine in 1:10. I shoot a lot of the RCBS 100gr. cast boreriders, and they work fine in my 1:10 .243 down to 500 fps, and up to 2600 fps.