Deerslayer15,
I grew up in WV and hunt Lewis Co. every year. I killed my first deer at age 14 with a 243 handloaded with 100gr. Remington PSPCLs. I have never had a problem taking deer. I will readily admit that ALL of my deer kills have been inside 200 yards, most were less than 100. I chose the 30-06 since it would be my one gun, thick or thin, close or far, factory or handloads, etc. that I'd choose hands down for any deer any place. I have used a 280 for two years now and have grown rather fond of it. I don't shoot out to 400 yards, but the cartridge is capable of it even if I'm not. If you don't handload, a 270,30-06, or 308 would serve you for any deer. I say that since I am not sure of the availability of 7MM-08 or 280 ammo in your area. If available, then those two would serve you just fine. I handload my centerfire ammo and worry less about velocity and more about consistant accuracy and game performance. Good luck.