A lot of folks really seem to like the 7mm-08 in the 15" Encore, which should still be effective past 100 yards. If you're looking for pure knockdown power, the 44 Mag, 454 Casull, 480 Ruger, etc. should really get the job done. Are you limited in the choice of cartridges in your state (are there any regualtions regarding the use of certain pistol cartridges?)?