You can probably get away with it one time, but I'm pretty sure that any extended shooting at all will streach the frame. Some time back a fellow reported rechambering a Handi to 300 Win Mag, and streaching the frame with 30 rounds or so. I don't think any gain from such a load would be any more useful in the real world than a 500 grain load that is only producing 30,000-40,000 psi. It is either Garret or Buffalo Bore that loads a 500 grainer to 1600 fps that is safe for use in the Handi. Look through the manuals some more, I'm sure there is a 40,000psi load that will do what you want.