For a sidearm that may be used in the spur-of-the-moment situation, the 357, 41, 44, any of these are going to do about the same on a small animal like a Coyote. I like my 629, but the 357 125gr. is a good Varmit load.
For planned situations or shooting out of my truck, I like my Super 14 in
223 with the 50V-Max or 55Gr. BT. Funny that the 30-30AI was mentioned, I have that Super 14 barrel as well, which shoots the 150BT at
2,400FPS. I shot an Antelope at 187 yards with it & I am fine with it with
Deer/Antelope/Varmits out to 250 yards. Oso45-70, I know you were joking, but it did remind me of what a fine barrel my 30-30AI is, but I
still think in terms of the 223 usually for Varmits & these rounds offer a totally different type of Varmit shooting that a straight wall case cannot provide, but I enjoy both type of weapons.