I've shot a few hundred Lyman 212 GCs and perhaps a dozen 250 grain GCs using H322 and H335. The 212s shot fairly well and gave good velocity. The 250 jacketed were just shot to see if they would stabliish. They did, but I don't see them as being of any use.
Except for very special circumstances, the 180 grain bullets seem ideal for the cartridge. Heavier bullets might give a bit more penetration, but the 180s have all the penetration needed for whitetail, and that is about the biggest animal I would hunt with a single shot Max.