The .375H&H is so efficient at burning powder that 20" is plenty. As for performance, each inch correlates to approximately 50fps. I have a Sako with a 20" barrel and it is plenty accurate out to at least 300 yards. I can't see much past that so I haven't pushed it. The one caveat is that if you are shooting the lighter bullets, 210-235 grain, that you load hot, a longer barrel will add stability.