myronman3: Actually, the 200 gn 357 load at 1335'/sec is a factory listed Winchester load from earlier loading data. It may sound like a hot load but the pressure comparisons list their 158 gn loads as running between 38 and 42K psi. The 200 gn/1335'/sec load using WW296 is listed at 35K psi.
I have found that in my N-frame S&Ws this load shoots very easily. This load was also one of my favorites in the Model 19 on the silhouette course. The 200 grainers would take the ram at 200 yds cleanly - not so with the 158s from a 4" bbl.
It isn't a matter of hotrodding a load - I have never really had much luck with that and consider it dangerous, which is why I am glad I have found a heavy factory loading that works in my revolvers.
And, I am pretty familiar with the 40 caliber/10mm rounds out there, having wildcatted, developed and hunted with the first 10mm round based on the 45 acp case. In my particular case design, which the 40 Super now closely approximates, a 180 gn (or 170 or 160 all from the same mold using different hardness mixtures) at 1300'/sec (+ or - ) is the most accurate and lethal from my pistols. The closest a factory loading in the 10mm that compares favorably is the old 200 gn load at 1200'/sec (one of the original Norma loads for the Bren Ten).
All this however is just FYI. Whatever works well for one hunter may not work for another.
The question posted was whether the 45 acp was a good backup for coyote, wolf or bear at about 30 yds and Questor's response was accurate - the 45 is a bit lame when it comes to hunting. About the best thing you can do for the 45 acp if you intend to use it as backup against predatory game is to stuff it with either the RCBS 223 grn cast flatnose at about 875-900'/sec (easily reloadable without hotrodding) or some flying ashtrays at around 1100'/sec.
If sabotloader does not reload, then the off the shelf 180 - 200 grain fast moving hollowpoints would most likely be his best choice for wolf or coyote. If he thinks he will encounter bear, he might want to consider the 230 grain Federals. And if he is still concerned he should carry more rifle ammo. Mikey.