I've always used Winchester Large Pistol primers in the 45 Colt, wether it's a 270gr @ 800 fps or a 325gr@ 1,300 fps. I haven't had any problems using H110, WLP primers and 310gr LFN bullets from Leadhead's.
In a Ruger 21.5gr of H110 under a 310gr LFN is a good starting point, that load does right around 1,050 fps from my 7.5" Blackhawk.