Brig33, any of the 3 calibers you already have will do the job well with the right loads with the .223 being optimum as already stated, but you'll love the 22-250 anyway. Mine makes consistent kills between 400 and 600yds on a regular basis. Buy one, practice with it and stretch your range. Youll be amazed at what the firearm and the shooter are each capable of. Enjoy! :agree: