My first Contender barrel was a .45LC/.410 and I still think it is the most fun to shoot. I get the best accuracy from heavy bullets, mainly, the 300 XTP, at about 1100 fps. I have mounted a Tasco RedDot sight on the vent rib of the barrel using a shotgun vent rib mount from B-Square. With the red dot I can use the shotgun and the .45. I wouldn't hesitate to shoot at a deer within 75 yds, mainly because the dot would cover too much target at a greater range. I have thought about removing the rib and having the barrel drilled and tapped so I could use a regular scope base, but I use it alot for a snake gun sans the red dot.
Be sure to remove choke when shooting any type of solid projectile!! That would lead to "stripping" for sure!