Be careful you're satisfied with the answers to this question. I know of 2 hunters, one personally, who lost moose in N. Ontario last year. Both were shot with .300Win. Mags. using 180gr. spire point bullets (I don't know the maker). Both shots were 100yds., give or take a few yards, and both were lung shots, judging by the clearness of the blood. It was late afternoon in both cases and both animals made it to the bush and were not found. They couldn't be tracked for long as darkness set in. I'm sure both died, but what a tragic loss. Maybe the bullets didn't expand or it wasn't a solid hit I don't know, but do be sure of your bullet. Best wishes.
Cal - Montreal