:cb2: It depends on the use, and how much.
For a carry gun, I'd get a 2.5" 686. One of the most perfectly balanced handguns on the market. It's like pointing your finger. The 686 will also have a much better trigger.
For fun and field use, I'd get the GP100 (and a trigger job). It's a tank that can take anything you put in it, and will still be passed on down to your grandkids. It will stand up to more use and abuse than any other DA revolver. Plus, it doesn't cost as much.
However, that said, I love my S&W revolvers, and for most shooters that take care of their weapons, the 686 will outlast their owners for sure. It's a sturdy gun. Plus, you can get it in 7 or even 8 shot models.
So, back to the beginning—what are you going to use it for?