The .35 Remington has killed many thousands of both in its century-long career, it is a proven hunting cartridge. The classic 200-grain RN bullet is the factory load of choice, although in a 14" T/C the velocity is a bit low. This can be improved to rifle speeds safely with handloads. I've used the 180 Speer and 150 CoreLokt with success on deer, harvested a moose with the 250 Speer. No bear, but it would do it.