I would say you are real close on the estimate, I would start with about 14 grains of 4759 and start watching the bore, adding a half a grain until the burn cleaned up. That would be looking for an accurate load...
The rifle that I use anything similar in is an old perry slug gun barrel on a hiwall action. It's not quite a .40 cal but larger that the 38, say a 39 cal. I use as 38-72 case and breach seat a 330 grain bullet over 18 grains of 4759.