Handi, I agree with your one load for all thinking, although for me, I like shooting and trying different bullets. I also agree with Fred M. though, I have been working up a 140 Accubond load for my 7mm Mag and it will be my one hunting load. It is plenty for deer and elk, so why handicap yourself with a 160? The 140 may be a bit more accurate in your .280 and you will have just a bit more velocity to work with. But if your heart is set on the 160, go for it with no second thoughts, it will work great for you! IMO the bonded bullets are the best of both worlds (deep penetration & great expansion/energy transfer). Good luck, good shooting, and God Bless!