Just today I was reading about a 22-378 Weatherby. The guy built it just to roast barrels quickly to test some new coating for some outfit. It shot a 80 grain bullet at 4600 fps, and a 40 grain bullet at 5000 fps. Used 117grains of powder to do it, and the barrel was destroyed (throat moved forward 4 inches, fire cracked, chunks missing, etc) after 64 shots. That's what happens when you neck down a really big case to a small bore.