Hello from Georgia,
I think that the new big bore pistols follow the same trend the started in rifles a number of years back. For many years a 30-30 was plenty sufficient for deer hunting and the 30-06 was considered almost too big.
Now we have the 7 MAG, 300MAGs and all the short mag folks shooting 200 - 250 pound deer with a gun far more powerful than is really needed. Hey, to each his own. But as far as I am concerned, my .44 mag loaded with the load my pistol prefers will take any game I will ever aim at. As soon as I see that it is not enough gun, than I will be down at my gun dealer to order up a 500 S&W. Collecting guns is a hobby that I enjoy, but I am a realist when it comes to understanding exactly what it takes to dispatch a big game animal.
Dave