If your refering to +p 45LC hunting loads thats not going to work. Those loads are designed only for Ruger, Dan Wesson, Freedom Arms and Thompson Contenders. If your refering to CB's self defense ammo that should be fine. I'd recomend Buffalo Bore's standard pressure 45LC load if your were thinking of the former which drives a 255 swc at 1000fps and should handle most chores.