I've loaded thousands of rounds of ammunition on my Dillon. It will change calibers in minutes. I bought more powder slides and when set for a load I use often, I mark it with a felt tip pen with the load. This way, when I change calibers or loads I don't have to go through the hassle of resetting that single slide. I still recheck with the scale when I start up. I did find that if you have more than one powder measure assembly, they don't match well enough to use interchangably, as to the bell, so I marked them as to what calibers they have been matched with. ANYTHING that breaks will be replaced free forever. Assistance with problems always attended to by phone. I have friends who have two Dillons, one set up for large primers and one for small, making it even faster to change calibers in that direction.