A bit to much power for the little fellows. The standard soft points will usually exit golf ball size on a coyote and up to baseball sized on a fragile cat. You may want to look into black hills ammo, I know they were loading bearclaws in 223, maybee they are loading a thick jacketed bullet for the 22-250. The fellow that suggested the 40 gr vmax (Hornady Varmint Express) may have an idea. I have used the 55 gr on cats and had a messy end. The 40 may be small enough to not punch through. I know from experience the fmj round works poorly on coyote, and I assume you will be hunting for all three types at the same time. Generally I only use the 22-250 when I expect shots to be over 300 yards, on the small fellows I try to shoot a front to back shot instead of broadside. About a quarte of the time I still ruin the hide. Good Luck