I used to aviod fixed sights like the plague for years.
Then, after a few experiences,one with a vaquero, another an old S&W model 10, I changed my ignorant ways.
Nearly every gun I've bought or shot with fixed sights is real close with suitible loads of ammo, or easily adjusted for with handloading or "kentucky" windage.
'Course there has always got to be that lemon out there that shoots two foot left and six feet high-so far I've just been lucky
And you've got to pick the load for the gun, not the gun for the load, and if you've got something special in mind, like say a real heavy or light bullet for the caliber or something.......well...........