I use an Aimpoint-mounted Smith 624 (sold my .44 magnums, too much of a good thing!)
My handload is the Keith 250 gn swc, hardcast over 13.2 gns of 2400, alox lube. Velocity runs 1050 fps and will put 10 shots into 1.5" off sandbags at 25 yds. Might not sound very powerful but it shoots through washing machines at 75 yds with that hard-cast Keith bullet. I've only recovered one bullet from game.
This gun/load has accounted for 21 whitetails, three javelina and two hogs over the years.
HH to all!