I don't get out as much for squirrels as I'd like to anymore. When I do, I take my 5.5" stainless Single-Six, loaded with Federal HPs(Wal-Mart specials! LOL!). I don't like scopes on handguns, so it's iron sights only for me.
I used to get out for squirrels quite a bit, and I've killed piles of both grey, and fox squirrels with my revolvers. Now you've got me itching to go again. I might just have to try to bust me a few pretty soon!